Collaborators RRTC Project Descriptions National Database Contact Us PRINCIPAL INVESTIGATOR: CO-INVESTIGATORS: Margaret Struchen, Ph.D. Angelle Sander, Ph.D. Charles Contant, Ph.D. Claudia Robertson, M.D. Alex Valadka, M.D. Gerard Francisco, M.D. Cindy Ivanhoe, M.D. This website is supported by a grant from the National Institute on Disability and Rehabilitation Research, U.S. Department of Education for the Rehabilitation Research and Training Center on Rehabilitation Interventions following TBI (Grant No. H185A200211-95) at TIRR (The Institute for Rehabilitation and Research).
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R1: Determination of the Risk Factors Associated with Poor Outcome Following Mild Traumatic Brain Injury Principal Investigator: Walter M. High, Ph.D. Co-Investigators:H. Julia Hannay, Ph.D., Margaret Struchen, Ph.D., Angelle Sander, Ph.D., Charles Contant, Ph.D., Claudia Robertson, M.D., Alex Valadka, M.D., Gerard Francisco, M.D., Cindy Ivanhoe, M.D. Specific Aim: To determine the impact of physiological, cognitive, affective, personality, and external factors on outcome following mild TBI Sample: 164 persons, age 18 years or greater, with mild TBI (Glasgow Coma Scale (GCS) score of 13 to 15 and no neurological abnormalities) and 112 persons with complicated mild TBI (GCS 13 to 15, but abnormalities evident on neuroimaging or on neurological exam); subjects recruited from the acute care facility of a county hospital that serves the indigent and uninsured members of the community, as well as some patients with insurance; the county hospital population is approximately 1/3 Caucasian, 1/3 Hispanic, and 1/3 African-American. Design: Assessment of pre-injury risk factors and of neuropsychological performance within 1 week of injury; assessment of outcome at 3 months post-injury. Predictor Variables: Demographic variables (age, gender, race. education, marital status, vocational history); acute injury variables (injury severity, CT/MRI results, associated trauma); pre-injury history (substance use, medical history, neurological history, psychiatric history, pre-existing disabilities, social/leisure activities); presence of injury-related litigation or workman’s compensation; neuropsychological test performance at 1 week post-injury; pre-injury psychological functioning (depressive symptoms, symptoms of Posttraumatic Stress Disorder; stress and coping, anger, pain, substance use, personality); family resources. Primary Outcome Measures: New York Head Injury Family Interview Problem Checklist; SF-36; Community Integration Questionnaire; Brief Symptom Inventory; Disability Rating Scale; Glasgow Outcome Scale; # of days until return to productive activity Contact Information Walter M. High, Jr., Ph.D. Director Brain Injury Research Center (BIRC) 4007 Bellaire Blvd., Suite EE Houston, Texas 77025 713-666-9550 http://braininjuryresearch.org
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